IPv6 can be an issue for certain applications running on Windows 2008. A quick way to completely disable IPv6 on any flavor of 2008 including Server Core is to run the command below at an elevated privileged cmd prompt then reboot your server.
c:\>reg add hklm\system\currentcontrolset\services\tcpip6\parameters /v DisabledComponents /t REG_DWORD /d 255 |